跳到主要內容

提子皮抗衰老



 人類自古以來對「長生不老」趨之若鶩,時至今日「抗衰老」仍是不少人窮一生希望掌握的秘密,香港大學醫學院生物化學系教授周中軍的團隊正向着謎底邁進,他 們發現提子皮所含的物質「白藜蘆醇」可刺激動物體內的「長壽基因」,並研發出治療早老症的藥物,已在動物實驗證實可延長近三成壽命,去年起更開始於內地安 排病人參與試驗。憑藉對衰老研究領域的貢獻,周中軍獲得本年度裘槎優秀科研者獎。

早老症屬非常罕見的疾病,病發率約四百萬分 之一,患者一般在六個月大已開始衰老,普遍不能活過十三歲。周中軍指,此病並非遺傳病,而是由基因突變而起。他在過去十多年的研究中發現,提子等水果表皮 所含的物質「白藜蘆醇」可刺激動物體內的「長壽基因」SIRT1,保護幹細胞以達致延長早老症動物的壽命。

去年底開展臨床試驗

有關研究過去一直利用老鼠進行實驗,發現把「白藜蘆醇」用於患有早老症的老鼠,可延長其壽命兩至三成;若用於正常的老鼠,牠們的毛髮也會明顯變得有光澤,而且白毛比較少,不過就未見有延長壽命的效果,亦未能肯定可以延緩衰老。
研究團隊去年底首次於內地開展臨床試驗,現時有八名由兩歲至十六歲的早老症患者正試用新藥,他們會先接受三個月的觀察期,然後按體重服食不同劑量的新藥物,持續六個月,再監察藥效。八名病人已開始服藥一個月,尚待結果。
周中軍強調,「長壽基因」SIRT1絕非愈活躍愈好,過去有研究發現,如果能夠令動物體內的「長壽基因」增加至原本的兩倍,抗衰老效果最 理想;但如果十倍的「長壽基因」被激活,反而有機會破壞其他非幹細胞的正常細胞。因此,究竟要服食或攝取多少分量的「白藜蘆醇」,才可令SIRT1增兩 倍,以及應用在人體的效果,仍待更多研究確定。
現時坊間有部分加入「白藜蘆醇」的營養補充劑已獲美國食品及藥物管理局(FDA)批准出售。周中軍笑言自己偶爾也有服用這些補充劑,但目前仍未能以科學方法證實這些產品的抗衰老成效,他期望日後可獲更多資源作相關的深入研究。

Professor Zhongjun ZHOU (HKU), Professor, Department of Biochemistry, Li Ka Shing Faculty of Medicine. Professor Zhou is an internationally recognised expert on laminopathy-based premature aging and extracellular matrix.  His major research field is bone development, blood vessel development and aging.  His research focuses on premature aging and aging-associated diseases, as well as extracellular matrix.  Professor Zhou and his team identified prelamin A as an in vivo substrate for metalloproteinase Zmpste24 through a genetic approach and explained how Lamin A’s abnoramality influences development and aging.  His team demonstrated lamin A activates longevity protein SIRT1 to maintain the stem cell potency.  He revealed for the first time that mutation in nuclear structural protein lamin A compromises DNA repair, which contributes to accelerated aging in Hutchinson-Gilford Progeria Syndrome.  His work provides important insights into the molecular mechanisms underlying Hutchinson-Gilford Progeria Syndrome (HGPS). This has an important implication in normal aging and aging–related human degenerative disorders.

2015 croucher award 

Activation of SIRT1 by Resveratrol requires lamin A

resveratrol rescues SIRT dependent Adult Stem cell decline

another link 

Dr John Pezzuto:  cancer chemopreventive action of resveratrol 

Genes and Development: Structural basis for allosteric, substratedependent stimulation of SIRT1 activity by resveratrol and here in English and in pdf 

留言

這個網誌中的熱門文章

越南香草

Ngo ~ "N-gaw" Mui ~ "Moo-ee" Ngo ~ "N-gaw" Mui ~ "Moo-ee" Ngo ~ "N-gaw" Mui ~ "Moo-ee" Ngo (N-gaw) ,  Mui  (Moo-ee )  Cilantro Ngo Gai (N-gaw guy), Mui Tau (Moo-ee Tao), Ngo Tau (N-gaw Tao)   Mexican Coriander,  Sawtooth Coriander, Culantro    娥女帝(拼音), 刺芹   特徵:娥女帝是短株形的植物,氣味清淡,葉邊呈鋸齒形,十分容易辨認。來源地:越南。 功效:和白夏差不多,娥女帝亦有祛濕、解毒及驅風的療效。建議食法: Pho,  (Bánh Xeò) 越南煎餅, 炒菜,湯,咖哩 Ngo Gai ~ "N-gaw guy" Mui Tau ~ "Moo-ee Tao" Ngo Tau ~ "N-gaw Tao" - See more at: http://vietworldkitchen.typepad.com/blog/vietnamese-herb-primer.html#sthash.I9rzkzwI.dpuf Rau Ram (Rau Rahm) Vietnam Coriander, Laksa Leaf, "Vietnamese mint(actually not a mint)" Peppery, quite spicy. In salad Hung (Hoong), , Hung Lang (Hoong Lang) Spearmint.  Vietnamese coriander Hung Lui (Hoong Lou-ee), Hung Diu(Hoong Zee-ew) round mint used in salad Hung Cay (Hoong Kay) Mint Rau Que, Hung Que (H...

沖田博文 Hirofumi Okita 60cm F3.25 dobsonian telescope

  the making mirror from Mike Lockwood webpage   youtube uwakina bokura other ATMers in Japan blueforest anettai  

劣質洗衣機入水喉

上面白色是最易找到,$2x. 但漏水. 灰色, $4x, 是假冒 "MADE IN ITALY"  假冒 "MADE IN ITALY"  的標緻  左面是白色膠喉的喉頭, 右面是灰色膠喉的喉頭, 上圖左面是真正 好貨 ( MADE IN ITALY )灰色膠蓋.右面是冒牌 白色膠蓋. 膠蓋在安裝扭緊時爆開  上圖左面是真正 好貨 , 標了其他規格.右面是冒牌, 單單印了 MADE IN ITALY  好貨的膠蓋是可以下移, 露出喉頭及黑色軟膠墊 黑色軟膠墊是有坑紋. 質感較柔軟. 緊後可以"迫實"水龍頭 及喉蓋, 沒有滲漏 正板 MADE IN ITALY 賣 $4x, 價錢絕對合理. 冒牌貨在旺角新填地街買的, 也是$4x. 真是要小心!!! NB: MADE IN ITALY 是否真正 意大利制造實在無從考 証