what is protein folding? wiki Protein folding is the physical process by which a protein chain acquires its native 3-dimensional structure, a conformation that is usually biologically functional, in an expeditious and reproducible manner. It is the physical process by which a polypeptide folds into its characteristic and functional three-dimensional structure from a random coil. Each protein exists as an unfolded polypeptide or random coil when translated from a sequence of mRNA to a linear chain of amino acids. How to contribute? donate your idle computation power to folding@home We need your help to tackle the Coronavirus! With COVID-19 becoming a bigger public health threat, the Folding@home team is contributing to the open-science effort to understand this pathogen, and help develop life-saving therapies, and you can help us! facebook verge