港大幹細胞及老化研究發現抗衰老啟動機制治療早老症及衰老相關退化病現曙光

香港大學李嘉誠醫學院生物化學系研究人員於2005年發現核纖層蛋白Lamin A基因變異可損壞DNA修復功能，而令基因組變得不穩定，導致早老症。經過六年努力，研究人員進一步解構抗衰老啟動機制，發現Lamin A這種人體蛋白質能有效刺激長壽基因SIRT1，令幹細胞自我保護、自我更新。港大研究人員還發現葡萄皮層的物質「白藜蘆醇」可以通過Lamin A有效刺激SIRT1以延緩衰老，相信這些新發現可以發展成早老症及抗衰老療法，為未來香港人口老化所帶來的問題提供治療良方。此項突破性研究剛發表於最新一期國際權威學術期刊 -《細胞代謝》(Cell Metabolism)中。

是項研究耗時六年，由香港大學李嘉誠醫學院生物化學系副教授周中軍博士領導，由助理教授（研究）劉寶華博士等完成。周中軍博士指出：「我們利用兒童早老症（Hutchinson-Gilford Progeria Syndrome, HGPS）的小鼠模型，首次證明增加幹細胞數量、活化幹細胞功能可以改善健康，並延長壽命。由於正常衰老與HGPS早老症有著類似的分子機理，因此本項研究對於延緩衰老、預防及治療與衰老相關的退化症具有重要意義，並對香港這個全球最長壽地區的人口老化問題帶來重要啟示。」

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