phases of chronic hepatitis B

 

WHO issues its first guidelines for chronic hepatitis B patients:

The "WHO guidelines for the prevention, care and treatment of persons living with chronic hepatitis B infection" lay out a simplified approach to the care of people living with chronic hepatitis B, particularly in settings with limited resources.
The guidance covers the full spectrum of care from determining who needs treatment, to what medicines to use, and how to monitor people long-term.

Key recommendations include:

• the use of a few simple non-invasive tests to assess the stage of liver disease to help identify who needs treatment;
• prioritizing treatment for those with cirrhosis - the most advanced stage of liver disease;
• the use of two safe and highly effective medicines, tenofovir or entecavir, for the treatment of chronic hepatitis B; and
• regular monitoring using simple tests for early detection of liver cancer, to assess whether treatment is working, and if treatment can be stopped.

The special needs of specific populations, such as people co-infected with HIV, as well as children and adolescents, and pregnant women are also considered.
The two recommended medicines are already available in many countries as generics, and thus are relatively inexpensive, costing as little as US$ 5 per person per month. “Because for so many people treatment is life-long it is important that patients can access these medicines at the lowest possible price” says Dr. Wiktor.

A number of countries are beginning to develop hepatitis B treatment programmes, and the newly-released document also provide guidance on how to organize hepatitis care and treatment services. “For example, countries need to think about ways to improve access to medicines and how best to deliver quality care that builds on existing health services and staff,” says Dr Philippa Easterbrook, from the WHO Global Hepatitis Programme.

Treatment can prolong life for people already infected with hepatitis B, but it is also important to focus on preventing new infections. WHO recommends that all children are vaccinated against hepatitis B, with a first dose given at birth. Some countries, particularly in Asia, have reduced the rates of childhood hepatitis B infection through universal childhood vaccination. The challenge now is to scale up efforts to ensure that all children worldwide are protected from the virus.

Another route of infection is through the reuse of medical equipment, in particular of syringes. WHO has recently launched a new policy on injection safety that will also help prevent new hepatitis B infections. The policy calls for the worldwide use of “smart” syringes to prevent the re-use of syringes or needles.

the guidelines in pdf